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মঙ্গলবার, ১ মে, ২০১২

The Wanted Apologize To Christina Aguilera, Sort Of

'We shouldn't have said it,' says Tom Parker.
By Gil Kaufman

The Wanted
Photo: Derek Storm/ Splash News

Sometimes, sorry is the hardest word to say. That's the tough new celebrity lesson learned by The Wanted member Tom Parker, who got hit pretty hard by Christina Aguilera's fans last week after he went on a New York radio station and tore into  "The Voice" coach Christina Aguilera, calling her a "total bitch."

After dropping the b-bomb several more times and claiming that the singer-turned-reality competition judge refused to look at or speak to the British lad band, fellow member Siva Kaneswaran added, "she was quite rude."

Well, Xtina's fans were not impressed and started flaming the group, and two days after dissing her, Parker walked the comments back a bit, according to TMZ. Caught by the gossip site's cameras outside Hollywood's Mondrian hotel on Sunday, Parker said, "We shouldn't have said it, to be honest with you. We just think manners cost nothing, you know what I mean? The rest of the judges were really nice, and she didn't even walk over to us and talk to us. We apologize for the comment."

Told that the original dis was all over Google when The Wanted's name was searched, Parker shook his head and lamented, "I know!" During the original radio appearance, The Wanted were also asked to compare their interactions with Aguilera on "The Voice" with an earlier meeting with "American Idol" judge Jennifer Lopez, when Max George planted a kiss on J.Lo and then the boys openly pined for her hand in marriage backstage. And, as you can probably expect, they definitely preferred one experience to the other. "[Aguilera] was a bit scary, to be honest," George said. Then, when asked about smooching Lopez, he laughed: "Yeah, well J.Lo's hot, Christina's nothing special."

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MSU invention could help pharmaceutical industry save money

Public release date: 30-Apr-2012
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Contact: Layne Cameron
layne.cameron@ur.msu.edu
517-353-8819
Michigan State University

EAST LANSING, Mich. Two Michigan State University researchers have invented a protein purifier that could help pharmaceutical companies save time and money.

The details of the invention, which appear in a recent issue of the journal Langmuir, demonstrate that MSU chemists Merlin Bruening and Greg Baker's high-performance membranes are highly suitable for protein purification, a crucial step in the development of some new drugs.

Purifying proteins, the process of isolating a single, desired protein from all others, is an expensive, time-consuming hurdle that contributes to the high cost of some prescription drugs. Obtaining pure proteins, however, is a necessary step to increasing these drugs' effectiveness and safety. Streamlining the process could help manufacturers reduce costs, speed new drugs to consumers and reduce pharmaceutical costs, Bruening said.

"The membrane devices that we've manufactured can simplify protein purification by rapidly capturing the desired protein as it flows through membrane pores," said Bruening, who has patented the process and is working to scale up his invention. "Our membranes have two to three times more capacity than existing commercial devices, and they should reduce the purification process time substantially. Typically, our procedures are complete in 30 minutes or less."

The pursuit of a comparable, but complex purification procedure led to the discovery of the researchers' simpler invention. Bruening and his colleague were trying to grow extended polymer chains in the membranes in a multistep, oxygen-free process. Untangling the complexities of the first method led to the revelation that direct adsorption of acidic polymers at low pH is much simpler yet accomplishes the same task of creating extended polymer in the pores. (The purifier uses adsorption rather than absorption; the filter attracts contaminants to its surface rather than sucks them up like a sponge.)

"Once our findings began steering us toward the simpler solution, we began developing simple processes to modify membranes by simply flowing polymer solutions through the membranes," Bruening said.

The next challenge for Bruening and his colleagues will be to upscale his invention so that rapid protein purification with inexpensive membranes becomes a standard for not only pharmaceutical companies, but also researchers trying to rapidly isolate proteins to determine their structure and function.

###
Fellow MSU chemists Baker, Somnath Bhattacharjee, Jinlan Dong, Yiding Ma, Stacy Hovde and James Geiger and contributed to the paper.

Michigan State University has been working to advance the common good in uncommon ways for more than 150 years. One of the top research universities in the world, MSU focuses its vast resources on creating solutions to some of the world's most pressing challenges, while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

MSU invention could help pharmaceutical industry save money Public release date: 30-Apr-2012
[ | E-mail | Share ]
Contact: Layne Cameron
layne.cameron@ur.msu.edu
517-353-8819
Michigan State University

EAST LANSING, Mich. Two Michigan State University researchers have invented a protein purifier that could help pharmaceutical companies save time and money.

The details of the invention, which appear in a recent issue of the journal Langmuir, demonstrate that MSU chemists Merlin Bruening and Greg Baker's high-performance membranes are highly suitable for protein purification, a crucial step in the development of some new drugs.

Purifying proteins, the process of isolating a single, desired protein from all others, is an expensive, time-consuming hurdle that contributes to the high cost of some prescription drugs. Obtaining pure proteins, however, is a necessary step to increasing these drugs' effectiveness and safety. Streamlining the process could help manufacturers reduce costs, speed new drugs to consumers and reduce pharmaceutical costs, Bruening said.

"The membrane devices that we've manufactured can simplify protein purification by rapidly capturing the desired protein as it flows through membrane pores," said Bruening, who has patented the process and is working to scale up his invention. "Our membranes have two to three times more capacity than existing commercial devices, and they should reduce the purification process time substantially. Typically, our procedures are complete in 30 minutes or less."

The pursuit of a comparable, but complex purification procedure led to the discovery of the researchers' simpler invention. Bruening and his colleague were trying to grow extended polymer chains in the membranes in a multistep, oxygen-free process. Untangling the complexities of the first method led to the revelation that direct adsorption of acidic polymers at low pH is much simpler yet accomplishes the same task of creating extended polymer in the pores. (The purifier uses adsorption rather than absorption; the filter attracts contaminants to its surface rather than sucks them up like a sponge.)

"Once our findings began steering us toward the simpler solution, we began developing simple processes to modify membranes by simply flowing polymer solutions through the membranes," Bruening said.

The next challenge for Bruening and his colleagues will be to upscale his invention so that rapid protein purification with inexpensive membranes becomes a standard for not only pharmaceutical companies, but also researchers trying to rapidly isolate proteins to determine their structure and function.

###
Fellow MSU chemists Baker, Somnath Bhattacharjee, Jinlan Dong, Yiding Ma, Stacy Hovde and James Geiger and contributed to the paper.

Michigan State University has been working to advance the common good in uncommon ways for more than 150 years. One of the top research universities in the world, MSU focuses its vast resources on creating solutions to some of the world's most pressing challenges, while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

[ | E-mail | Share ]
?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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Square Competitor SalesVu Ups Its Game With New Features For Restaurants, Retailers & More

SalesVu, the maker of a mobile payments service designed for business customers, is launching a major update with SalesVu 2.0, live now in the iTunes App Store. The company is somewhat similar to Square, in that it also includes a dongle that plugs into an iPhone or iPad and works alongside an accompanying mobile application. However, the company is focused on providing tools that address more complex business needs than simply taking credit cards via a mobile device. For example, SalesVu currently offers real-time analytics reporting and the ability for businesses to post offers directly to Facebook through social sharing?mechanisms. With the release of SalesVu 2.0, a number of improvements have been added for business users, including things like receipt printing, barcode scanning, employee timekeeping, and online order processing, to name a just few.

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Captive British aid worker killed in Pakistan

QUETTA, Pakistan (AP) ? The body of a British Red Cross worker held captive in Pakistan since January was found in an orchard Sunday, his throat slit and a note attached to his body saying he was killed because no ransom was paid, police said.

Khalil Rasjed Dale, 60, was managing a health program in the city of Quetta in southwestern Pakistan when armed men seized him from a street close to his office. The identities of his captors are unknown, but the region is home to separatist and Islamist militants who have kidnapped for ransom before.

The director-general of the International Committee of the Red Cross condemned the "barbaric act."

"All of us at the ICRC and at the British Red Cross share the grief and outrage of Khalil's family and friends," said Yves Daccord.

Dale's throat had been slit, according to Safdar Hussain, a doctor who examined the body.

Quetta police chief Ahsan Mahboob said the note attached to it read: "This is the body of Khalil who we have slaughtered for not paying a ransom amount."

Militants and criminal gangs often kidnap wealthy Pakistanis and less commonly, foreigners.

British Foreign Secretary William Hague condemned Dale's killing, and said "tireless efforts" had been under way to secure his release after he was kidnapped.

Khalil had worked for the Red Cross for years, carrying out assignments in Somalia, Afghanistan and Iraq, the group said.

Quetta, the capital of Baluchistan province, lies close to the Afghan border and for decades has hosted thousands of refugees from that country. The Red Cross operates clinics in the city that treat people wounded in the war in Afghanistan, including Taliban insurgents.

Much of Baluchistan and the tribal regions close to Afghanistan are out of Pakistani government control, and make good places to keep hostages. Large ransoms are often paid to secure their release, but such payments are rarely confirmed.

There are at least four other foreigners being held in Pakistan.

Last August, a 70-year-old American humanitarian aid worker was kidnapped from his house in the Punjabi city of Lahore. Al-Qaida claimed to be holding the man, Warren Weinstein, and said in a video he would be released if the United States stopped airstrikes in Afghanistan, Pakistan, Somalia and Yemen.

In March, a Swiss couple held captive for eight months by the Taliban turned up at an army checkpoint close to the Afghan border. Insurgents have claimed a large ransom was paid to secure their freedom. That has not been confirmed by Pakistani or Swiss authorities, who are unlikely to acknowledge it even if they did.

The couple was kidnapped in Baluchistan.

Also Sunday, American missiles killed three suspected Islamist militants sheltering in an abandoned school in North Waziristan, said intelligence officials, who did not give their names because they were not authorized to speak to reporters.

The strike comes as the U.S. is trying to rebuild its relationship with Pakistan, which opposes the missile attacks and has demanded they stop. The frequency of the attacks, which critics say kill innocents and energize the insurgency, has dropped dramatically this year.

___

Associated Press Writer Rasool Dawar in Peshawar contributed to this report.

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